With Haxe you can use the language, libraries and concepts you are familiar with to create full-featured desktop apps.
When aiming for apps with a native look, you can use HaxeUI library, which uses several ways to build native UI for each platform. There is support for WxWidgets when targetting C++, which provides real native look that lets developers create applications for Windows, Mac OS X, Linux.
More flexible interfaces can be crafted with NME or OpenFL.
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A structured static database for easing collaboration on game projects. Built with and for Haxe, using node-webkit.
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Node Webkit lets you run a Webkit shell on the desktop, meaning you can use Haxe and HTML5 / JS technologies to build your app. It provides full access to the Haxe/NodeJS APIs so your app can integrate with the system.
A framework for building native apps using Haxe/React.
UI Component Library to create user experiences for mobile, web and desktop on a wide range of Haxe platforms. HaxeUI integrates with a number different frameworks.
OpenFL enables creative expression for the desktop, mobile and web. Enterprise applications and best-selling games are made with OpenFL, publishing native, Flash and HTML5 applications using one seamless toolset.
Use WxWidgets to create desktop apps with a truly native look and feel on all major platforms. Works with the C++ and Neko targets, and integrates with NME. Start with these Waxe tutorials by Cambiata (Haxe 2).
Let us know and we might add it to this list.